Overview of “Emerging Targeted Therapies for Relapsed/Refractory Acute Myeloid Leukemia: Mechanisms, Challenges, and Future Directions”

Published in the International Journal of Research and Analytical Reviews (IJRAR), Volume 12, Issue 2, April 2025, this review article by Dr. Farheen Zuber Mohmed from Weill Cornell Medicine, New York, USA, explores the evolving landscape of targeted therapies for relapsed or refractory (R/R) acute myeloid leukemia (AML), a challenging hematologic malignancy. Despite advances in chemotherapy and stem cell transplantation, R/R AML remains difficult to treat, prompting the development of novel targeted approaches.

The paper highlights key targeted therapies, including:

FLT3 Inhibitors (e.g., Midostaurin, Gilteritinib), which target FLT3 mutations prevalent in 30% of AML cases, with Gilteritinib showing a median overall survival of 9.3 months.
IDH1/2 Inhibitors (e.g., Ivosidenib, Enasidenib), which promote differentiation of leukemic cells and are FDA-approved.
BCL-2 Inhibitors (e.g., Venetoclax), enhancing response rates when combined with hypomethylating agents.
Menin Inhibitors (e.g., Revumenib), showing early promise in trials for AML with specific genetic rearrangements.
CD47 Blockade (e.g., Magrolimab), an investigational therapy that boosts macrophage-mediated clearance of leukemic cells.

The review addresses challenges such as resistance, toxicities, and limited efficacy in complex cases, while outlining future directions. Advances in single-cell sequencing, epigenetic profiling, and trials combining targeted therapies with immunotherapies (e.g., CAR-T cells) signal a move toward precision oncology, offering hope for improved outcomes in R/R AML.

Funded by the National Institutes of Health, this paper provides a comprehensive resource for understanding the current and future therapeutic landscape for this aggressive disease.

Advances in Immunotherapy for Multiple Myeloma: From Monoclonal Antibodies to CAR-T Cells and Beyond

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Advances in Immunotherapy for Multiple Myeloma: From Monoclonal Antibodies to CAR-T Cells and Beyond
\nPublished in the International Journal Dental and Medical Sciences Research, Volume 7, Issue 2, Mar-Apr

Authored by Farheen Zuber Mohmed of Weill Cornell Medicine,

Overview:

this comprehensive review examines the groundbreaking role of immunotherapy in treating multiple myeloma (MM), a challenging hematologic cancer affecting around 35,000 individuals yearly in the U.S. The paper provides an in-depth analysis of cutting-edge immunotherapies, including monoclonal antibodies like daratumumab, CAR-T cell therapies such as idecabtagene vicleucel, and bispecific antibodies like teclistamab, which have demonstrated remarkable overall response rates (70-90%) and improved progression-free survival in relapsed/refractory MM patients. It explores the mechanisms behind these therapies, supported by data from phase II/III trials and preclinical studies, while addressing key obstacles such as antigen loss, T-cell exhaustion, and treatment-related toxicities like cytokine release syndrome. The review also highlights innovative approaches, including dual-target CAR-T cells, antibody-drug conjugates, and the use of AI and genomic profiling for tailored treatments. Emphasizing the need for overcoming resistance and enhancing accessibility, the paper calls for collaborative efforts to drive sustained remissions and equitable care, making it an essential guide for advancing MM research and clinical practice.

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Image"},"viewId":"viewId_-3746400402427872808","heading":{"text":"Discover Dr. Farheen ZuberMohmed Patel’s Impact & Acheivements.","viewType":"text","properties":{"show":true,"padding":"18,0,0,0","paddingWeb":"0,0,0,100","textSize":"20","textSizeWeb":"40","fontStyle":"medium","textColor":"#ff1d5732","fontFamily":"Poppins","textAlignment":"center","background":"#00000000","backgroundType":"color","overlayColor":"#00000000","showWeb":true},"editorTitle":"Heading"},"summary":{"text":"

Dr. Farheen ZuberMohmed,

Hematologist Onco-Geneticist | Global Leader in Cancer Research

About :

Dr. Farheen ZuberMohmed, a Hematologist Onco-Geneticist dedicated to advancing the fight against cancer through groundbreaking research and clinical innovation. As Head of the K4 Research Unit in the Division of Hematologic Malignancies at the World Health Organization (WHO) since January 2025 ; she has worked in cutting-edge initiatives to unravel the genetic underpinnings of blood cancers. She is one of the youngest leaders in this prestigious role, a testament to my commitment and expertise.

Currently, transitioning to the role of Scientific Director at the Ludwig Institute for Cancer Research, where she will drive transformative discoveries in oncology. Her work bridges science and hope, aiming to deliver tangible improvements in patient outcomes worldwide.

Professional Journey

• World Health Organization (2016–Present): Joined WHO in 2016, focusing on hematologic malignancies. On January 2025, made Head of the K4 Research Unit, spearheading innovative research into cancer genetics and targeted therapies.

• Ludwig Institute for Cancer Research (2025–Present): In transition to Scientific Director, poised to shape the future of global cancer research through strategic leadership and collaboration.

• European Health Forum: Proud member of the Authors Panel, contributing thought leadership to shape health policy and research directions across Europe.

Awards & Accolades

Dr Farheen ZuberMohmed Patel’s contributions to cancer research have been recognised globally through prestigious awards and honors:

• Best Youngest Medical Researcher (October 2024): Awarded by the Congress of Medical Researches and Experts at Palais des Nations, Geneva, for pioneering contributions to oncology at a young age.

• Best Research Paper Presentation (October 2024): Honored by the Congress of Medical Researches and Experts, Geneva, for an outstanding presentation on advancements in hematologic malignancy research.

• Excellence in Cancer Research and Clinical Trials (November 2024): Recognized by the European Association for Cancer Research (EACR) in Paris for impactful work in clinical trials and cancer research.

• Youngest Medical Researcher 2024–2025 (January 2025): Celebrated by the Indian Medical Association, Ahmedabad Branch, for exceptional achievements in medical research.

• Wall of Fame, WHO Oslo (2025): Her name is enshrined among distinguished contributors at the World Health Organization in Oslo, Norway, reflecting my global impact.

Our Mission

With a passion for discovery and a commitment to patients, we strive to unlock new frontiers in cancer treatment. Our research focuses on the intersection of genetics and oncology, developing personalized therapies that target the root causes of hematologic malignancies. By fostering collaboration across institutions and borders, we aim to accelerate progress toward a cancer-free future.

Connect with us

Stay updated on my latest research, publications, and speaking engagements and more.

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